Ampicillin – a semi-synthetic penicillin, bactericidal effect, is acid. Active against gram-neobrazuyuschih penicillinase (Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae) and Gram (Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Salmonella spp., Shigella spp., Proteus mirabilis, Haemophilus influenzae, Haemophilus influenzae) organisms.
Oxacillin – penitsillinazoustoychivy semisynthetic antibiotic of the penicillin group, is acid; It has bactericidal activity against gram-positive bacteria (Staphylococcus spp., Streptococcus spp., including Streptococcus pneumoniae, Actinimyces spp., Bacillus anthracis, Corynebacterium diphtheriae, anaerobic spore-forming rods, including Clostridium), Gram negative cocci (Neisseria gonorrhoeae, Neisseria meningitidis), E.coli, Pr.mirabilis, H.influenzae, K.pneumoniae, Actinomyces spp, Treponema spp.
Both antibiotics excreted by the kidneys, partly with bile.
For repeated administrations do not cumulate.
Bacterial infections caused by susceptible pathogens: sinusitis, tonsillitis, otitis media; bronchitis, pneumonia; cholangitis, cholecystitis; pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, cervicitis; infections of skin and soft tissues: erysipelas, impetigo, secondarily infected dermatoses and others.
Prevention of postoperative complications in surgical interventions (including on the background of immunodeficiency), neonatal infections (infection of the amniotic fluid, neonatal respiratory violation, requiring the application of resuscitation measures, the risk of aspiration pneumonia).
Hard occurring infections (sepsis, endocarditis, meningitis, puerperal infection).
: Hypersensitivity, infectious mononucleosis, lymphatic leukemia.
With care – children born to mothers with hypersensitivity to penicillins.
Dosing and Administration
Single dose for adults and children over 14 years – 0.5-1 grams daily – 2-4 years Children 3-7 years – 100 mg / kg / day, 7-14 – 50 mg / kg / day. Duration of treatment – from 5-7 days to 2 weeks. The daily dose divided into 4-6 receptions.
Allergic reactions: hives, skin flushing, angioedema, rhinitis, conjunctivitis; fever, arthralgia, eosinophilia, in rare cases, anaphylactic shock; superinfection, goiter, change in taste, nausea, vomiting, diarrhea, rarely pseudomembranous enterocolitis, leukopenia, neutropenia, anemia.
If signs of anaphylactic shock must be urgent action is taken to remove the patient from the state: the introduction of epinephrine, corticosteroids (hydrocortisone or prednisone) and antihistamines, conduct artificial respiration if necessary.
Interaction with other medicines
Antacids, glucosamine, laxatives, food, aminoglycosides -zamedlyayut and reduce absorption; ascorbic acid increases the absorption of the drug.
Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) have a synergistic effect; bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) – antagonistic.
It improves the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index); reduces the effectiveness of oral contraceptives, medicines, which is formed during the metabolism of para-aminobenzoic acid, ethinyl estradiol – the risk of bleeding “breakthrough.”
Diuretics, allopurinol, phenylbutazone, nonsteroidal anti-inflammatory drugs, probenecid – reduce tubular secretion, increase the concentration of drug in plasma, which increases the risk of toxic effect.
Allopurinol increases the risk of skin rash.
In exchange treatment medication necessary to control the state of the functions of blood, liver and kidneys.
The possibility of superinfection (due to growth insensitive to it microflora) requires a corresponding change in antibiotic therapy.
In patients with increased sensitivity to penicillins, possible allergic cross-reaction with cephalosporin antibiotics.
Can be used during pregnancy when indicated.
Provided with breast milk in low concentrations. If necessary, use during lactation should decide the issue of termination of breastfeeding.
With high doses in patients with renal insufficiency possible toxic effects on the central nervous system.
bayer proviron of 250 mg (0.125 g ampicillin and 0.125 g oxacillin).
On 20 bayer proviron in banks orange glass or jar of glass.
On 20 bayer proviron in a polymeric jar.
10 bayer proviron in blisters. Bank or 1, 2 blisters with instruction on use – in a stack of cardboard.